This conversation between Peyton and Derek in 608 is so relevant.
P: "I think we're all looking for a life that makes sense somehow, and I am very, very happy for you that you found that."
D: "And have you found that?"
P: "Yes. I have. I mean it sneaks up on you, right? But one day you look at your life, and it has purpose, and someone that makes you feel very special, and friends. And it's like all of a sudden, all the time and pain that it took to get there, it just doesn't matter anymore."